Signaling in Oncogenesis, Angiogenesis, and Permeability

EMBO J 2026 May;45(9):3306-3331. doi: 10.1038/s44318-026-00742-y. Epub 2026 Apr 7. Abstract The ubiquitin-specific protease (USP) USP9X is a human deubiquitinase (DUB) with a large number of described targets and cellular roles. In cancer, USP9X is found as an oncogene or as a tumour suppressor depending on context, and its utility as a target for cancer therapy remains unclear. We here describe WEHI-092, a piperazine-based USP9X-specific small-molecule inhibitor, which bind

Nature Communications volume 16, Article number: 9374 (2025) Abstract Yes-associated protein (YAP), a key effector of the Hippo pathway, regulates gene expression and promotes tumorigenesis. YAP is conventionally considered “undruggable”, however, targeted protein degradation offers a promising approach to address the challenges associated with targeting this oncogenic protein. In this study, through naïve nanobody phage library screening, we identify multiple nanobodies agai

Stabilizing MARCH7 as a ferro-guardian against ferroptosis Cell Online nowApril 27, 2026 Highlights • Multi-omics analysis identifies MARCH7 as a master regulator of ferroptosis • MARCH7 degrades NCOA4 by K48 ubiquitination to reduce the labile iron pool • MARCH7 inhibits iron uptake by restricting TFR1 translocation by K63 ubiquitination • Stabilization of MARCH7 by EmodAn inhibits ferroptosis in vitro and in vivo Summary Ferroptosis is an iron-dependent form of regulated ce

Stem cell control in the lung by an autocrine injury-activated Igf complex Science 16 Apr 2026 Vol 392, Issue 67 Structured Abstract INTRODUCTION Adult stem cells are rapidly, but transiently, activated by injury to repair damaged tissue. Repeated or chronic injury predisposes to cancer. Although there has been progress in identifying and characterizing mammalian stem cells and homeostatic mitogens that regulate their proliferation, injury-activated mitogens, the mechanisms t

Deltaviruses spread through a viral Trojan Horse Cell March 2026

Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder Cell Volume 189, Issue 3 p765-782.e31February 05, 2026 Highlights • Lysosomal proteomics of brain cell types • Identification of previously uncharacterized and cell-type-specific lysosomal proteins • SLC45A1 is a neuron-specific lysosomal sugar transporter • SLC45A1 loss drives lysosomal and mitochondrial dysfunction Summary Mutations in lysosomal genes cause neur

Nature volume 650 , pages 951–960 (2026) Abstract Primary sensory neurons in dorsal root ganglia (DRG) have long axons and a high demand for mitochondria, and mitochondrial dysfunction has been implicated in peripheral neuropathy after diabetes and chemotherapy 1 , 2 . However, the mechanisms by which primary sensory neurons maintain their mitochondrial supply remain unclear. Satellite glial cells (SGCs) in DRG encircle sensory neurons and regulate neuronal activity and pain

Autophagolysosomal exocytosis inverts Src kinase onto the cell surface in cancer Science 12 Mar 2026 Vol 391, Issue 6790 ditor’s summary Discovering cell surface proteins that are specific to cancer cells and not normal cells can create opportunities for safer delivery of toxic drugs to tumors. Delaveris et al . identified a family of proteins that are delivered to the cell surface in cancer but not in healthy tissues (see the Perspective by Pfannenstein and Meyer). One such

Ageing promotes metastasis via activation of the integrated stress response Nature 11 March 2026 Abstract Lung cancer predominantly affects older individuals, yet how physiological ageing influences tumour evolution remains poorly understood 1 . Here we show that ageing reprograms the evolutionary trajectory of KRAS -driven lung adenocarcinoma, limiting primary tumour growth while promoting metastatic dissemination through epigenetic activation of the integrated stress respon