Signaling in Oncogenesis, Angiogenesis, and Permeability

Membrane potential mediates the cellular response to mechanical pressure Cell online Dec 2025 Highlights Cellular biomass density increases with cell number density in confluent tissues Membrane potential reflects cell density and mechanical pressure Membrane potential is an important regulator of cell number density and growth Membrane potential controls Hippo signaling via the transmembrane protein FAT1

Melbourne, 1-2 dec

Yanis Macé presented his PHD work entitled " status and functions of the deubiquitinase enzyme CYLD during programmed cell death and associated inflammation" under the supervision of Dr. Nicolas Bidère in front of an international jury presided by Dr Izabela Sumara Dr Mathieu Bertrand Dr Nieves Peltzer Dr Virginie Petrilli

Nature Communications volume 16 , Article number: 8336 (2025) Creative experiences may enhance brain health, yet metrics and mechanisms remain elusive. We characterized brain health using brain clocks, which capture deviations from chronological age (i.e., accelerated or delayed brain aging). We combined M/EEG functional connectivity ( N  = 1,240) with machine learning support vector machines, whole-brain modeling, and Neurosynth metanalyses. From this framework, we reanaly

Nature volume 647, pages 517–527 (2025) Abstract Phenotype switching is a form of cellular plasticity in which cancer cells reversibly move between two opposite extremes: proliferative versus invasive states 1 , 2 . Although it has long been hypothesized that such switching is triggered by external cues, the identity of these cues remains unclear. Here we demonstrate that mechanical confinement mediates phenotype switching through chromatin remodelling. Using a zebrafish mode

Science 21 Aug 2025 Vol 389, Issue 6762 DOI: 10.1126/science.adz0972 Editor’s summary Enlarged lysosomal vacuoles are observed in many conditions, including aging, infection, and prion and other neurodegenerative diseases. However, little is known about how these vacuoles are formed, precluding understanding of their pathophysiological functions. Through unbiased proteomics, Yang et al . identified lysosomal vacuolator (LYVAC, also known as PDZD8) as a key driver of lysosomal

The new SMLM system from Abbelight is all setup in the Institute Thanks to the people involved from Abbelight, SOAP team and INSERM CRCI2NA Thanks to the funders: Ligue, INSERM, IT Cancer

Science 25 Sep 2025 Vol 390, Issue 6771 Editor’s summary A grand challenge in molecular biology is understanding which proteins in an organism interact with which other proteins, ideally with high-resolution accuracy. Zhang et al . developed a deep learning model for predicting protein complex structures and applied it to the human interactome. Their method involves processing additional data from available genomes and using it to supplement multiple sequence alignments. They

The Finnish Brain Tumor Research Association (FiBTRA), in collaboration with Turku Bioscience Centre (University of Turku & Åbo Akademi University), is organizing the 7th  Annual Finnish Symposium on Brain Tumors which will take place on October 23–24, 2025 , in Turku, Finland.

Science ; 9 Oct 2025; Vol 390, Issue 6769 DOI: 10.1126/science.adl4089 Structured Abstract INTRODUCTION Cytosolic nucleic acid–sensing pathways have emerged as promising therapeutic targets to enhance the efficacy of immune checkpoint blockade, especially in immunologically “cold” tumors. Activation of these pathways stimulates type I interferon (IFN-I) signaling and the expression of interferon-stimulated genes (ISGs), promoting immune cell recruitment and potentially conver