Signaling in Oncogenesis, Angiogenesis, and Permeability

Nature volume 650 , pages 951–960 (2026) Abstract Primary sensory neurons in dorsal root ganglia (DRG) have long axons and a high demand for mitochondria, and mitochondrial dysfunction has been implicated in peripheral neuropathy after diabetes and chemotherapy 1 , 2 . However, the mechanisms by which primary sensory neurons maintain their mitochondrial supply remain unclear. Satellite glial cells (SGCs) in DRG encircle sensory neurons and regulate neuronal activity and pain

Autophagolysosomal exocytosis inverts Src kinase onto the cell surface in cancer Science 12 Mar 2026 Vol 391, Issue 6790 ditor’s summary Discovering cell surface proteins that are specific to cancer cells and not normal cells can create opportunities for safer delivery of toxic drugs to tumors. Delaveris et al . identified a family of proteins that are delivered to the cell surface in cancer but not in healthy tissues (see the Perspective by Pfannenstein and Meyer). One such

Ageing promotes metastasis via activation of the integrated stress response Nature 11 March 2026 Abstract Lung cancer predominantly affects older individuals, yet how physiological ageing influences tumour evolution remains poorly understood 1 . Here we show that ageing reprograms the evolutionary trajectory of KRAS -driven lung adenocarcinoma, limiting primary tumour growth while promoting metastatic dissemination through epigenetic activation of the integrated stress respon

DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality Structured Abstract INTRODUCTION DNA-protein cross-links (DPCs) are highly toxic lesions in which proteins become covalently attached to DNA, blocking essential processes such as replication and transcription. To maintain genome stability, cells rely on specialized repair mechanisms that remove DPCs. The protease SPRTN was the first enzyme identified to resolve these lesions by cleaving

A lysosomal requiem for glioblastoma cells Laura Merlet, Margaux Le Guyon, Julie Gavard Abstract Once viewed solely as degradative compartments, lysosomes shape cell fate through signaling, metabolism, and communication. In glioblastoma, their rewiring underlies plasticity, invasion, and resistance to therapies. This forum explores lysosomal dynamics in brain tumors and therapeutic strategies targeting lysosomal vulnerabilities, offering fresh perspectives for precision appro

Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity Abstract Targeting innate immunity holds promise in cancer immunotherapy, particularly in improving checkpoint inhibitors. However, the use of agonists of the promising innate receptors TLRs and STING 1 , 2 , 3 , 4 is facing challenges. Here we examined the antitumour function of the α-kinase 1 (ALPK1) receptor for bacterial ADP-heptose (ADP-Hep) 5 , 6 , 7 . Treatment of mice with ADP-Hep induced mult

The integrated stress response promotes immune evasion through lipocalin 2 Nature 2026 Abstract Cancer cells activate the integrated stress response (ISR) to adapt to stress and resist therapy 1 . ISR signals converge on activating transcription factor 4 (ATF4), which controls cell-intrinsic transcriptional programs that are involved in metabolic adaptation, survival and growth 2 , 3 . However, whether the ISR–ATF4 axis influences anti-tumour immune responses remains mostly u

Tumor-derived arachidonic acid reprograms neutrophils to promote immune suppression and therapy resistance in triple-negative breast cancer Immunity Volume 58, Issue 4 p909-925.e7April 08, 2025 Highlights • ICB and chemotherapy-resistant TNBC cells demonstrate heightened lipid accumulation • Lipid accumulation is associated with increased arachidonic acid (AA) synthesis • Cancer cell-derived AA reprograms tumor neutrophils to be more immunosuppressive • Reprogrammed neutroph