Signaling in Oncogenesis, Angiogenesis, and Permeability

Tumor-derived arachidonic acid reprograms neutrophils to promote immune suppression and therapy resistance in triple-negative breast cancer Immunity Volume 58, Issue 4 p909-925.e7April 08, 2025 Highlights • ICB and chemotherapy-resistant TNBC cells demonstrate heightened lipid accumulation • Lipid accumulation is associated with increased arachidonic acid (AA) synthesis • Cancer cell-derived AA reprograms tumor neutrophils to be more immunosuppressive • Reprogrammed neutroph

Cell February 2026 Highlights • Meningeal blood vessel blockage impedes GBM progression in mice • Dura rBAMs display superior tumor antigen-presentation function in GBM models • Meningeal blood vessel blockage expands rBAMs and enhances anti-tumor T cell activation • rBAM abundance correlates positively with survival in GBM patients Summary The dura mater, the outermost meningeal layer that samples and presents central nervous system (CNS)-derived antigens, is a pivotal inter

Platelet-derived integrin- and tetraspanin-enriched tethers exacerbate severe inflammation Science 22 Jan 2026 Vol 391, Issue 6783 INTRODUCTION Integrins are a family of heterodimeric transmembrane receptors that link the extracellular matrix to the cytoskeleton and regulate adhesion, migration, and signaling in many cell types. The platelet integrin αIIbβ3 (also designated GPIIb/IIIa) is among the best-studied integrins and is indispensable for hemostasis and thrombosis. Bey

Science 8 Jan 2026 Vol 391, Issue 6781 Editor’s summary Gliomas with mutations in the gene isocitrate dehydrogenase  ( IDH ) are the most common type of malignant brain tumor in young adults. The IDH mutation has been proposed to occur at an early stage of glioma development, but the precise “cell of origin” has yet to be identified. Park et al . report that glial progenitor cells (GPCs), including oligodendrocyte progenitor cells (OPCs), carry the earliest IDH  mutation (se

Nature volume 649 , pages 227–236 (2026) Abstract The endoplasmic reticulum (ER) is a highly interconnected membrane network that serves as a central site for protein synthesis and maturation 1 . A crucial subset of ER-associated transcripts, termed secretome mRNAs, encode secretory, lumenal and integral membrane proteins, representing nearly one-third of human protein-coding genes 1 . Unlike cytosolic mRNAs, secretome mRNAs undergo co-translational translocation, and thus r

SIGLEC12 mediates plasma membrane rupture during necroptotic cell death Nature volume 649 , pages 460–466 (2026) Abstract Necroptosis is a form of lytic cell death that is overactivated during infections and in inflammatory pathologies 1 . NINJ1 was recently found to be a mediator of plasma membrane rupture (PMR) during pyroptosis, toxin-induced necrosis, apoptosis, and ferroptosis 2 , 3 , but the mediator of PMR during necroptotic cell death remained unknown. Here, using a

Microbial signals in primary and metastatic brain tumors Nature Medicine volume 31 , pages 3675–3688 (2025) Abstract Gliomas and brain metastases are associated with poor prognosis, necessitating a deeper understanding of brain tumor biology and the development of effective therapeutic strategies. Although our group and others have demonstrated microbial presence in various tumors, recent controversies regarding cancer-type-specific intratumoral microbiota emphasize the impo