

Event: Julie at the 7th FIBTRA, Turku, Finland
The Finnish Brain Tumor Research Association (FiBTRA), in collaboration with Turku Bioscience Centre (University of Turku & Åbo Akademi University), is organizing the 7th Annual Finnish Symposium on Brain Tumors which will take place on October 23–24, 2025 , in Turku, Finland.


Journal Club: MTAP deficiency confers resistance to cytosolic nucleic acid sensing and STING agonists
Science ; 9 Oct 2025; Vol 390, Issue 6769 DOI: 10.1126/science.adl4089 Structured Abstract INTRODUCTION Cytosolic nucleic acid–sensing pathways have emerged as promising therapeutic targets to enhance the efficacy of immune checkpoint blockade, especially in immunologically “cold” tumors. Activation of these pathways stimulates type I interferon (IFN-I) signaling and the expression of interferon-stimulated genes (ISGs), promoting immune cell recruitment and potentially conver


Journal Club: A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
Editor’s summary Somewhat lacking in good looks, the naked mole rat gets attention because it is very long lived and highly resistant to cancer. Chen et al . revealed a molecular mechanism that contributes to successful aging in these rodents: a change in the enzyme cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS), which is known to sense cytosolic DNA and initiate immune defense responses (see the Perspective by Martinez et al .). Unlike human cGAS, whi
Journal Club: BDH2-driven lysosome-to-mitochondria iron transfer shapes ferroptosis vulnerability of the melanoma cell states
Nature Metabolism volume 7 , pages 1851–1870 (2025) Abstract Iron sustains cancer cell plasticity, yet it also sensitizes the mesenchymal, drug-tolerant phenotype to ferroptosis. This posits that iron compartmentalization must be tightly regulated. However, the molecular machinery governing organelle Fe(II) compartmentalization remains elusive. Here, we show that BDH2 is a key effector of inter-organelle Fe(II) redistribution and ferroptosis vulnerability during melanoma tra
Journal Club: Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy
Nature 2025 Abstract Perineural invasion (PNI) is a well-established factor of poor prognosis in multiple cancer types 1 , yet its...
Journal Club: Axonal injury is a targetable driver of glioblastoma progression
Nature 2025 Abstract Glioblastoma (GBM) is an aggressive and highly therapy-resistant brain tumour 1 , 2 . Although advanced disease has...


Highlight: DUBROVNIK CONFERENCE ON CANCERMECHANISMS AND THERAPEUTICS
Flash Talk & Posters: Jane Jardine & Margaux Le Guyon Selected Talk: Tiphaine Douanne Boehringer Ingleheim Scholarship: Tiphaine Douanne
Journal Club: DHRS13 suppresses differentiation and mitophagy in glioma via retinoic acid and mitochondrial reactive oxygen species
Nature Communications 16 , Article number: 6996 (2025) Abstract To elucidate the complex interplay of undifferentiated cancer cells in...


Highlight: Get Up, Stand Up, and ... Invade !
Glioblastome : quand une molécule suspend le mouvement des cellules tumorales Lire l'actualité par CNRS Biologie...

