Signaling in Oncogenesis, Angiogenesis, and Permeability

The Finnish Brain Tumor Research Association (FiBTRA), in collaboration with Turku Bioscience Centre (University of Turku & Åbo Akademi University), is organizing the 7th  Annual Finnish Symposium on Brain Tumors which will take place on October 23–24, 2025 , in Turku, Finland.

Science ; 9 Oct 2025; Vol 390, Issue 6769 DOI: 10.1126/science.adl4089 Structured Abstract INTRODUCTION Cytosolic nucleic acid–sensing pathways have emerged as promising therapeutic targets to enhance the efficacy of immune checkpoint blockade, especially in immunologically “cold” tumors. Activation of these pathways stimulates type I interferon (IFN-I) signaling and the expression of interferon-stimulated genes (ISGs), promoting immune cell recruitment and potentially conver

Editor’s summary Somewhat lacking in good looks, the naked mole rat gets attention because it is very long lived and highly resistant to cancer. Chen et al . revealed a molecular mechanism that contributes to successful aging in these rodents: a change in the enzyme cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS), which is known to sense cytosolic DNA and initiate immune defense responses (see the Perspective by Martinez et al .). Unlike human cGAS, whi

Nature Metabolism volume 7 , pages 1851–1870 (2025) Abstract Iron sustains cancer cell plasticity, yet it also sensitizes the mesenchymal, drug-tolerant phenotype to ferroptosis. This posits that iron compartmentalization must be tightly regulated. However, the molecular machinery governing organelle Fe(II) compartmentalization remains elusive. Here, we show that BDH2 is a key effector of inter-organelle Fe(II) redistribution and ferroptosis vulnerability during melanoma tra

Nature 2025 Abstract Perineural invasion (PNI) is a well-established factor of poor prognosis in multiple cancer types 1 , yet its...

Nature 2025 Abstract Glioblastoma (GBM) is an aggressive and highly therapy-resistant brain tumour 1 , 2 . Although advanced disease has...

Flash Talk & Posters: Jane Jardine & Margaux Le Guyon Selected Talk: Tiphaine Douanne Boehringer Ingleheim Scholarship: Tiphaine Douanne

Nature Communications 16 , Article number: 6996 (2025) Abstract To elucidate the complex interplay of undifferentiated cancer cells in...

Glioblastome : quand une molécule suspend le mouvement des cellules tumorales Lire l'actualité par CNRS Biologie...