Signaling in Oncogenesis, Angiogenesis, and Permeability

Nature volume 647, pages 517–527 (2025) Abstract Phenotype switching is a form of cellular plasticity in which cancer cells reversibly move between two opposite extremes: proliferative versus invasive states 1 , 2 . Although it has long been hypothesized that such switching is triggered by external cues, the identity of these cues remains unclear. Here we demonstrate that mechanical confinement mediates phenotype switching through chromatin remodelling. Using a zebrafish mode

Science 21 Aug 2025 Vol 389, Issue 6762 DOI: 10.1126/science.adz0972 Editor’s summary Enlarged lysosomal vacuoles are observed in many conditions, including aging, infection, and prion and other neurodegenerative diseases. However, little is known about how these vacuoles are formed, precluding understanding of their pathophysiological functions. Through unbiased proteomics, Yang et al . identified lysosomal vacuolator (LYVAC, also known as PDZD8) as a key driver of lysosomal

The new SMLM system from Abbelight is all setup in the Institute Thanks to the people involved from Abbelight, SOAP team and INSERM CRCI2NA Thanks to the funders: Ligue, INSERM, IT Cancer

Science 25 Sep 2025 Vol 390, Issue 6771 Editor’s summary A grand challenge in molecular biology is understanding which proteins in an organism interact with which other proteins, ideally with high-resolution accuracy. Zhang et al . developed a deep learning model for predicting protein complex structures and applied it to the human interactome. Their method involves processing additional data from available genomes and using it to supplement multiple sequence alignments. They

The Finnish Brain Tumor Research Association (FiBTRA), in collaboration with Turku Bioscience Centre (University of Turku & Åbo Akademi University), is organizing the 7th  Annual Finnish Symposium on Brain Tumors which will take place on October 23–24, 2025 , in Turku, Finland.

Science ; 9 Oct 2025; Vol 390, Issue 6769 DOI: 10.1126/science.adl4089 Structured Abstract INTRODUCTION Cytosolic nucleic acid–sensing pathways have emerged as promising therapeutic targets to enhance the efficacy of immune checkpoint blockade, especially in immunologically “cold” tumors. Activation of these pathways stimulates type I interferon (IFN-I) signaling and the expression of interferon-stimulated genes (ISGs), promoting immune cell recruitment and potentially conver

Editor’s summary Somewhat lacking in good looks, the naked mole rat gets attention because it is very long lived and highly resistant to cancer. Chen et al . revealed a molecular mechanism that contributes to successful aging in these rodents: a change in the enzyme cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS), which is known to sense cytosolic DNA and initiate immune defense responses (see the Perspective by Martinez et al .). Unlike human cGAS, whi

Nature Metabolism volume 7 , pages 1851–1870 (2025) Abstract Iron sustains cancer cell plasticity, yet it also sensitizes the mesenchymal, drug-tolerant phenotype to ferroptosis. This posits that iron compartmentalization must be tightly regulated. However, the molecular machinery governing organelle Fe(II) compartmentalization remains elusive. Here, we show that BDH2 is a key effector of inter-organelle Fe(II) redistribution and ferroptosis vulnerability during melanoma tra

Nature 2025 Abstract Perineural invasion (PNI) is a well-established factor of poor prognosis in multiple cancer types 1 , yet its...