Signaling in Oncogenesis, Angiogenesis, and Permeability

DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality Structured Abstract INTRODUCTION DNA-protein cross-links (DPCs) are highly toxic lesions in which proteins become covalently attached to DNA, blocking essential processes such as replication and transcription. To maintain genome stability, cells rely on specialized repair mechanisms that remove DPCs. The protease SPRTN was the first enzyme identified to resolve these lesions by cleaving

A lysosomal requiem for glioblastoma cells Laura Merlet, Margaux Le Guyon, Julie Gavard Abstract Once viewed solely as degradative compartments, lysosomes shape cell fate through signaling, metabolism, and communication. In glioblastoma, their rewiring underlies plasticity, invasion, and resistance to therapies. This forum explores lysosomal dynamics in brain tumors and therapeutic strategies targeting lysosomal vulnerabilities, offering fresh perspectives for precision appro

Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity Abstract Targeting innate immunity holds promise in cancer immunotherapy, particularly in improving checkpoint inhibitors. However, the use of agonists of the promising innate receptors TLRs and STING 1 , 2 , 3 , 4 is facing challenges. Here we examined the antitumour function of the α-kinase 1 (ALPK1) receptor for bacterial ADP-heptose (ADP-Hep) 5 , 6 , 7 . Treatment of mice with ADP-Hep induced mult

The integrated stress response promotes immune evasion through lipocalin 2 Nature 2026 Abstract Cancer cells activate the integrated stress response (ISR) to adapt to stress and resist therapy 1 . ISR signals converge on activating transcription factor 4 (ATF4), which controls cell-intrinsic transcriptional programs that are involved in metabolic adaptation, survival and growth 2 , 3 . However, whether the ISR–ATF4 axis influences anti-tumour immune responses remains mostly u

Tumor-derived arachidonic acid reprograms neutrophils to promote immune suppression and therapy resistance in triple-negative breast cancer Immunity Volume 58, Issue 4 p909-925.e7April 08, 2025 Highlights • ICB and chemotherapy-resistant TNBC cells demonstrate heightened lipid accumulation • Lipid accumulation is associated with increased arachidonic acid (AA) synthesis • Cancer cell-derived AA reprograms tumor neutrophils to be more immunosuppressive • Reprogrammed neutroph

Cell February 2026 Highlights • Meningeal blood vessel blockage impedes GBM progression in mice • Dura rBAMs display superior tumor antigen-presentation function in GBM models • Meningeal blood vessel blockage expands rBAMs and enhances anti-tumor T cell activation • rBAM abundance correlates positively with survival in GBM patients Summary The dura mater, the outermost meningeal layer that samples and presents central nervous system (CNS)-derived antigens, is a pivotal inter

Platelet-derived integrin- and tetraspanin-enriched tethers exacerbate severe inflammation Science 22 Jan 2026 Vol 391, Issue 6783 INTRODUCTION Integrins are a family of heterodimeric transmembrane receptors that link the extracellular matrix to the cytoskeleton and regulate adhesion, migration, and signaling in many cell types. The platelet integrin αIIbβ3 (also designated GPIIb/IIIa) is among the best-studied integrins and is indispensable for hemostasis and thrombosis. Bey

Science 8 Jan 2026 Vol 391, Issue 6781 Editor’s summary Gliomas with mutations in the gene isocitrate dehydrogenase  ( IDH ) are the most common type of malignant brain tumor in young adults. The IDH mutation has been proposed to occur at an early stage of glioma development, but the precise “cell of origin” has yet to be identified. Park et al . report that glial progenitor cells (GPCs), including oligodendrocyte progenitor cells (OPCs), carry the earliest IDH  mutation (se