Signaling in Oncogenesis, Angiogenesis, and Permeability

Nature volume 649 , pages 227–236 (2026) Abstract The endoplasmic reticulum (ER) is a highly interconnected membrane network that serves as a central site for protein synthesis and maturation 1 . A crucial subset of ER-associated transcripts, termed secretome mRNAs, encode secretory, lumenal and integral membrane proteins, representing nearly one-third of human protein-coding genes 1 . Unlike cytosolic mRNAs, secretome mRNAs undergo co-translational translocation, and thus r

SIGLEC12 mediates plasma membrane rupture during necroptotic cell death Nature volume 649 , pages 460–466 (2026) Abstract Necroptosis is a form of lytic cell death that is overactivated during infections and in inflammatory pathologies 1 . NINJ1 was recently found to be a mediator of plasma membrane rupture (PMR) during pyroptosis, toxin-induced necrosis, apoptosis, and ferroptosis 2 , 3 , but the mediator of PMR during necroptotic cell death remained unknown. Here, using a

Microbial signals in primary and metastatic brain tumors Nature Medicine volume 31 , pages 3675–3688 (2025) Abstract Gliomas and brain metastases are associated with poor prognosis, necessitating a deeper understanding of brain tumor biology and the development of effective therapeutic strategies. Although our group and others have demonstrated microbial presence in various tumors, recent controversies regarding cancer-type-specific intratumoral microbiota emphasize the impo

Membrane potential mediates the cellular response to mechanical pressure Cell online Dec 2025 Highlights Cellular biomass density increases with cell number density in confluent tissues Membrane potential reflects cell density and mechanical pressure Membrane potential is an important regulator of cell number density and growth Membrane potential controls Hippo signaling via the transmembrane protein FAT1

Melbourne, 1-2 dec

Yanis Macé presented his PHD work entitled " status and functions of the deubiquitinase enzyme CYLD during programmed cell death and associated inflammation" under the supervision of Dr. Nicolas Bidère in front of an international jury presided by Dr Izabela Sumara Dr Mathieu Bertrand Dr Nieves Peltzer Dr Virginie Petrilli

Nature Communications volume 16 , Article number: 8336 (2025) Creative experiences may enhance brain health, yet metrics and mechanisms remain elusive. We characterized brain health using brain clocks, which capture deviations from chronological age (i.e., accelerated or delayed brain aging). We combined M/EEG functional connectivity ( N  = 1,240) with machine learning support vector machines, whole-brain modeling, and Neurosynth metanalyses. From this framework, we reanaly

Nature volume 647, pages 517–527 (2025) Abstract Phenotype switching is a form of cellular plasticity in which cancer cells reversibly move between two opposite extremes: proliferative versus invasive states 1 , 2 . Although it has long been hypothesized that such switching is triggered by external cues, the identity of these cues remains unclear. Here we demonstrate that mechanical confinement mediates phenotype switching through chromatin remodelling. Using a zebrafish mode