Publications
2024
- Maghe C, Gavard J. Protocol for qualitative analysis of lysosome immunoprecipitation from patient-derived glioblastoma stem-like cells. Star Protocols 2024
- Renaud CCN, Nicolau Alves C, Maghe C, Trillet K, Jardine J, Escot S, David N, Gavard J, Bidere N. Necrosulfonamide causes oxidation of PCM1 and impairs ciliogenesis and autophagy. iScience 2024; 27: 109580.
- Maghe C, Trillet K, Andre-Gregoire G, Kerherve M, Merlet L, Jacobs KA, Schauer K, Bidere N, Gavard J. The paracaspase MALT1 controls cholesterol homeostasis in glioblastoma stem-like cells through lysosome proteome shaping. Cell Rep 2024; 43: 113631.
2023
- Renaud CCN, Trillet K, Jardine J, Merlet L, Renoult O, Laurent-Blond M, Catinaud Z, Pecqueur C, Gavard J, Bidere N. The centrosomal protein 131 participates in the regulation of mitochondrial apoptosis. Comms Biol 2023; 6: 1271.
- Andre-Gregoire G, Roux Q, Gavard J. Isolating plasma extracellular vesciles from mouse blood using size-exclusion chromatography, density gradient, and ultracentrifugation. Star Protocols 2023; 4: 102740.
- Lindberg MF, Deau E, Miege F, Greverie M, Roche D, George N, George P, Merlet L, Gavard J, Brugman SJT, Aret E, Tinnemans P, de Gelder R, Sadownik J, Verhofstad E, Sleegers D, Santangelo S, Dairou J, Fernandez-Blanco A, Dierssen M, Krämer A, Knapp S, Meijer L. Chemical, Biochemical, Cellular, and Physiological Characterization of Leucettinib-21, a Down Syndrome and Alzheimer’s Disease Drug Candidate. J Med Chem 2023; 66: 15648-70.
- Gavard J. Migrasome-derived nanoparticles: the chamber of secrets was opened again. FEBS J 2023; 290: 3355-8.
- Andre-Gregoire G, Gavard J. MLKL and the deathly hallows. Med Sci 2023; 39: 105-7.
- Decombis S, Bellanger C, Le Bris Y, Madiot C, Jardine J, Santos JC, Boulet D, Dousset C, Menard A, Kervoelen C, Douillard E, Moreau P, Minvielle S, Moreau-Aubry A, Tessoulin B, Roue G, Bidère N, Le Gouill S, Pellat-Deceunynck C, Chiron D. CARD11 gain of function upregulates BCL2A1 expression and promotes resistance to targeted therapies combination in B-cell lymphoma. Blood 2023; 142: 1543-55.
- Bikfalvi A, Alves da Costa C, Avril T, Barnier JV, Bauchet L, Brisson Cartron PF, Castel H, Chevet E, Chneiweiss H, Clavreul A, Constantin B, Coronas V, Daubon T, Dontenwill M, Ducray F, Enz-Werle N, Figarella-Branger D, Fournier I, Frenel JS, Gabut M, Galli T, Gavard J, Huberfeld G, Hugnot JP, Idbaih A, Junier MP, Mathivet T, Menei P, Meyronet D, Mirjolet C, Morin F, Mosser J, Cohen-Jonathan Moyal E, Rousseau V, Salzet M, Sanson M, Seano G, Tabouret E, Tchoghandjian A, Turchi L, Vallette FM, Vats S, Verreault M, Virolle T. Challenges in glioblastoma research: focus on the tumor microenvironment. Trends Cancer 2023; 9: 9-27.
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2022
- Taffoni C, Marines J, Chamma H, Guha S, Saccas M, Bouzid A, Chaves Valadeo AL, Maghe C, Jardine J, Park MK, Polak L, De Martino M, Vanpouille-Box C, Del Rio M, Gongora C, Gavard J, Bidere N, Song MS, Pineau D, Hugnot JP, Kissa K, Fontenille L, Blanchet FP, Vila IL, Laguette N. DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma. The EMBO J 2022; e111961.
- Kerherve M, Rosinska S, Trillet K, Zeinaty A, Feyeux M, Nedellec S, Gavard J. Neuropilin-1 modulates the 3D invasive properties of glioblastoma stem-like cells. Front Cell Dev Biol 2022; 10: 981583.
- Pagnuzzi-Boncompagni M, Picco V, Vial V, Planas-Bielsa V, Vandenberghe A, Daubon T, Derieppe MA, Montemagno C, Durivault J, Grépin R, Martial S, Doyen J, Gavard J, Pagès G. Antiangiogenic Compound Axitinib Demonstrates Low Toxicity and Antitumoral Effects against Medulloblastoma. Cancers 2022; 14(1): 70.
- Glemain A, Néel M, Néel A, André-Grégoire G, Gavard J, Martinet B, Le Bloas R, Riquin K, Hamidouab M, Fakhouri F, Bruneau S. Neutrophil-derived extracellular vesicles induce endothelial inflammation and damage through the transfer of miRNAs. J Autoimmunity 2022; 129: 102826.
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2021
- Trillet K, Jacobs KA, André-Grégoire G, Thys A, Maghe C, Cruard J, Minvielle S, Gonzales Diest S, Montagnac G, Bidère N, Gavard J. The glycoprotein GP130 governs the surface presentation of the G-protein coupled receptor APLNR. J Cell Biol 2021; 220(9): e202004114.
- Sabbagh Q, Andre-Gregoire G, Alves-Nicolau C, Dupont A, Bidere N, Jouglar E, Guével L, Frénel JS, Gavard J. The von Willebrand factor stamps plasmatic extracellular vesicles from glioblastoma patients. Sci Rep 2021; 11: 22792.
- Mancini SJC, Balabanian K, Corre I, Gavard J, Le Bousse-Kerdiles MC, Lazennec G, Louache F, Maguer-Satta V, Mazure NM, Mechta-Grigoriou F, Peyron JF, Trichet V, Herault O. Deciphering tumor niches: lessons from solid and hematological malignancies. Front Immunol 2021; 12: 766275.
- Renaud CR, Bidere N. Function of Centriolar Satellites and Regulation by post-translational Modifications. Front Cell Dev Biol 2021; 9: 780502.
- Huna A, Nawrocki-Raby B, Padilla-Benavides T, Gavard J, Coscoy S, Bernard D, Boissan M. Loss of the Metastasis Suppressor NME1, But Not of Its Highly Related Isoform NME2, Induces a Hybrid Epithelial–Mesenchymal State in Cancer Cells. Int J Mol Sci 2021; 22(7): 3718.
- Rosinska S, Gavard J. Tumor Vessels Fuel the Fire in Glioblastoma. Int J Mol Sci 2021; 22(12): 6514.
- Ghoroghi S, Mary B, Larnicol A, Asokan N, Klein A, Osmani N, Busnelli I, Delalande F, Paul N, Halary S, Gros F, Fouillen L, Haeberle AM, Royer C, Spiegelhalter C, André-Grégoire G, Mittelheisser V, Detappe A, Murphy K, Timpson P, Carapito R, Blot-Chabaud M, Gavard J, Carapito C, Vitale N, Lefebvre O, Goetz JG, Hyenne V. Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes. eLife 2021; 10: e61539.
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2020
- Thys A, Trillet K, Rosinska S, Gayraud A, Douanne T, Danger Y, Renaud CCN, Antigny L, Lavigne R, Pineau C, Com E, Vérité F, Gavard J, Bidère N. Serine 165 Phosphorylation of SHARPIN regulates the Activation of NF-κB. iScience 2020; 24(1): 101939.
- Sabbagh Q, Andre-Gregoire A, Guevel L, Gavard J. Vesiclemia: Counting on Extracellular Vesicles for Glioblastoma Patients. Oncogene 2020; 39(38): 6043-52.
- Jacobs KA, Maghe C, Gavard J. Lysosomes in glioblastoma: pump up the volume. Cell Cycle 2020; 19(17): 2094-104.
- Douanne T, Chapelier S, Rottapel R, Gavard J, Bidère N. The LUBAC participates in Lysophosphatidic Acid-induced NF-κB Activation. Cell Immunol 2020; 353: 104133.
- Maghe C, Jacobs KA, Bidère N, Gavard J. Glioblastome multiforme: les fleurs du MALT1. Med Sci 2020; 36(5): 452-4.
- Alves Nicolau C, Gavard J, Bidere N. TAK1 lessens the Activity of the Paracaspase MALT1 during T cell Receptor Signaling. Cell Immunol 2020; 353: 104115.
- Jacobs KA, André-Grégoire G, Maghe C, Li Y, Thys A, Harford-Wright E, Trillet K, Douanne T, Frenel JS, Bidere N, Gavard J. Paracaspase MALT1 regulates glioma cell survival by controlling endo-lysosome homeostasis. EMBO J 2020; 39: e102030.
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2019
- Douanne T, André-Grégoire G, Trillet K, Thys A, Papin A, Feyeux M, Hulin P, Chiron D, Gavard J, Bidere N. Pannexin-1 limits the production of proinflammatory cytokines during necroptosis. EMBO Rep 2019; 20(10): e47840.
- Guequen A, Zamorano P, Cordova F, Koning T, Torres A, Ehrenfeld P, Boric MP, Salazar-Onfray F, Gavard J, Duran WN, Quezada C, Sarmiento J, Sanchez FA. Interleukin-8 Secreted by Glioblastoma Cells Induces Microvascular Hyperpermeability Through NO Signaling Involving S-Nitrosylation of VE-Cadherin and p120 in Endothelial Cells. Front Physiol 2019; 10: 988.
- Douanne T, André-Grégoire G, Thys A, Trillet K, Gavard J, Bidère N. CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1. Cell Reports 2019; 27(6): 1657-65.
- Duarte A, André-Grégoire G, Trillet K, Thys A, Bidère N, Ribeiro-Silva A, Gavard J. Inhibition of mTOR in Head and Neck Cancer Cells Alters Endothelial Cell Morphology in a Paracrine Fashion. Mol Carcinogenesis 2019; 58: 161-8.
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2018
- Thys A, Douanne T, Bidere N. Post-translational Modifications of the CARMA1-BCL10-MALT1 Complex in Lymphocytes and Activated B-cell Like Subtype of Diffuse Large B-cell Lymphoma. Front Oncol 2018; 8: 498.
- Roux Q, Gavard J. Endothelial Cell-Cell Junctions in Tumor Angiogenesis. In Marmé D (eds) Tumor Angiogenesis. Springer 2018
- André-Grégoire G, Bidère N, Gavard J. Temozolomide Affects Extracellular Vesicles Released by Glioblastoma Cells. Biochimie 2018; 155: 11-15.
- Jacobs KA, Gavard J. 3D endothelial migration. Methods Mol Biol 2018; 1749: 51-58.
- Harford-Wright E, Gavard J. Apelin, the Devil Inside Brain Tumors. J Exp Neurosci 2018; 12: 1-3.
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2017
- Harford-Wright, Andre-Gregoire G, Jacobs KA, Treps L, Le Gonidec S, Leclair HM, Gonzalez-Diest S, Roux Q, Guillonneau F, Loussouarn D, Oliver F, Vallette FM, Foufelle F, Valet P, Davenport AP, Glen RC, Bidere N, Gavard J. Pharmacological targeting of apelin impairs glioblastoma growth. Brain 2017; 11(1): 2939–54.
- Treps L, Perret R, Edmond S, Ricard D, Gavard J. Glioblastoma stem-like cells secrete the pro-angiogenic VEGF-A factor in extracellular vesicles. J Extracell Ves 2017; 1(6).
- Jacobs KA, Harford-Wright E, Gavard J. Neutralizing gp130 interferes with endothelial-mediated effects on glioblastoma stem-like cells. Cell Death Diff 2017; 24(2): 384.
- Treps L, Gavard J. Assaying the action of secreted semaphorins on vascular permeability. In Semaphorins and Semaphorin Signalling, Methods Mol Biol 2017; 1493: 417-27.
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2016
- Harford-Wright E, Bidere N, Gavard J. β-escin selectively targets the glioblastoma-initiating cell population and reduces cell viability. Oncotarget 2016; 7(41): 66865-79.
- André-Grégoire G, Gavard J. Spitting out the demons: extracellular vesicles in glioblastoma. Cell Adh Migr 2016; 13: 1-9.
- Leclair HM, Andre-Gregoire A, Treps L, Azzi S, Bidere N, Gavard J. The E3 ubiquitin ligase MARCH3 controls the endothelial barrier. FEBS Lett 2016; 590(20): 3660-8.
- Douanne T, Bidere N. HOIL1 cleavage by MALT1, the knives are out. Receptors Clin Invest 2016; 3: e1410.
- Douanne T, Gavard J, Bidere N. The paracaspase MALT1 cleaves the LUBAC subunit HOIL1 during antigen receptor signaling. J Cell Sci 2016; 129: 1775-80.
- Treps L, Edmond S, Harford-Wright E, Galan-Moya EM, Schmitt A, Azzi S, Citerne A, Bidere N, Ricard D, Gavard J. Extracellular vesicle-transported Semaphorin3A promotes vascular permeability in glioblastoma. Oncogene. 2016; 35, 2615-23.
- Tjioe KC, Tostes Oliveira D, Gavard J. Luteolin impacts on the DNA-damage pathway in oral squamous cell carcinoma. Nutr Cancer 2016; 8: 1-10.
- Hanini A, El Massoudi M, Gavard J, Kacem K, Ammar S, Souilem O. Nanotoxicological study of polyol-made cobalt-zinc ferrite nanoparticles in rabbit. Environ Toxicol Pharmacol 2016; 45: 321-7.
- Hanini A, Lartigue L, Gavard J, Kacem K, Wilhelm C, Gazeau F, Chau F, Ammar S. Zinc substituted ferrite nanoparticles with Zn 0.9 Fe 2.1 O 4 formula used as heating agents for in vitro hyperthermia assay on glioma cells. J Magn Magn Mater 2016; 416: 315-20.
- Hanini A, Lartigue L, Gavard J, Schmitt A, Kacem K, Wilhelm C, Gazeau F, Chau F, Ammar S. Thermosensitivity profile of malignant glioma U87-MG cells and human endothelial cells following g-Fe2O3 NPs internalization and magnetic field application. RSC Adv 2016; 19: 15415-23.
2015
- Treps L, Gavard J. Tumor angiogenesis: when the Tree of Life turns bad. Med Sci 2015; 31(11): 989-95.
- Azzi S, Treps L, Leclair HM, Ngo H, Harford-Wright E, Gavard J. Desert Hedgehog/Patch2 axis contributes to vascular permeability and angiogenesis in glioblastoma. Front Pharmacol 2015; 6: 281.
- Majuelos-Melguizo J, Rodríguez MI, López-Jiménez L, Rodríguez-Vargas JM, Martín-Consuegra JM, Serrano-Sáenz S, Gavard J, de Almodóvar JM, Oliver FJ. PARP targeting counteracts gliomagenesis through induction of mitotic catastrophe and aggravation of deficiency in homologous recombination in PTEN-mutant glioma. Oncotarget 2015; 6(7): 4790-803.
- Dwyer J, Azzi S, Leclair HM, Georges S, Carlotti A, Treps L, Galan-Moya A, Alexia C, Dupin N, Bidere N, Gavard J. The guanine exchange factor SWAP70 mediates vGPCR-induced endothelial plasticity. Cell Commun Signaling 2015; 13: 12.
2014
- Leclair HM, Dubois SM, Azzi S, Dwyer J, Bidere N, Gavard J. Control of CXCR2 activity through its ubiquitination on K327 residue. BMC Cell Biology 2014; 15: 38.
- Hatchi EM, Poalas K, Cordeiro N, N’Debi M, Gavard J, Bidere N. Participation of the E3-ligase TRIM13 in NF-KB p65 activation and NFAT-dependent activation of c-Rel upon T-cell receptor engagement. Int J Biochem Cell Biol 2014; 54C: 217-22.
- Galan-Moya EM, Treps L, Oliver L, Chneiweiss H, Vallette FM, Bidere N, Gavard J. Endothelial secreted factors suppress mitogen deprivation-induced autophagy and apoptosis in glioblastoma stem-like cells. PLoS One 2014; 9(3): e93505.
- Dubois SM, Alexia C, Wu Y, Leclair HM, Leveau C, Schol E, Fest T, Tarte K, Chen Z, Gavard J, Bidere N. A catalytic-independent role for the LUBAC in NF-κB activation upon antigen receptor engagement and in lymphoma cells. Blood 2014; 123(14): 2199-203.
- Azzi S, Smith SS, Dwyer J, Leclair HM, Alexia C, Hebda JK, Dupin N, Bidere N, Gavard J. YGLF motif in the Kaposi Sarcoma Herpes Virus G protein coupled receptor adjusts NF-κB activation and paracrine actions. Oncogene 2014; 33(49): 5609-18.
- Azzi S, Gavard J. vGPCR, the great escape. Receptors Clin Invest 2014; 1: 3.
- Basti H, Hanini A, Levy M, Ben Tahar L, Herbst F, Smiri LS, Kacem K, Gavard J, Wilhelm C, Gazeau F, Chau F, Ammar S. Size tuned polyol-made Zn0.9M0.1Fe2O4 (M = Mn, Co, Ni) ferrite nanoparticles as potential heating agents for magnetic hyperthermia: from synthesis control to toxicity survey. Mat Res Express 2014; 1 (4): 045047.
2013
- Gavard J. Endothelial permeability and VE-cadherin : a wacky comradeship. Cell Adh Migr 2013; 7(6): 455-61.
- Azzi S, Hebda JK, Gavard J. Vascular permeability and drug delivery in cancers. Front Oncol 2013; 3: 211.
- Alexia C, Poalas K, Carvalho G, Zermili N, Dwyer J, Dubois SM, Hatchi EM, Cordeiro N, Smith SS, Castanier C, Le Guelte A, Wan L, Kang Y, Vazquez A, Gavard J, Arnoult D, Bidere N. The endoplasmic reticulum acts as a platform for ubiquitylated components of Nuclear Factor-κB signaling. Sci Signal 2013; 6: ra79.
- Cordeiro N, Bidere N. Visualization of fas-mediated death-inducing signaling complex formation by immunoprecipitation. Methods Mol Biol 2013; 979: 43-9.
- Hebda JK, Leclair HM, Azzi S, Roussel C, Scott MGH, Bidere N, Gavard J. The C-terminus region of beta-arrestin1 modulates VE-cadherin expression and endothelial cell permeability. Cell Commun Signal 2013; 11: 37.
- Treps L, Le Guelte A, Gavard J. Emerging roles of semaphorins in the regulation of epithelial and endothelial junctions. Tissue Barriers 2013; 1(1): e23272.
- Poalas K, Hatchi EM, Cordeiro N, Dubois SM, Leclair HM, Leveau C, Alexia C, Gavard J, Vazquez A, Bidere N. Negative regulation of NF-κB signaling in T lymphocytes by the ubiquitin-specific protease USP34. Cell Commun Signal 2013; 11: 25.
2012
- Le Guelte A, Galan-Moya EM, Dwyer J, Treps L, Kettler G, Hebda JK, Dubois S, Auffray C, Chneiweiss H, Bidere N, Gavard J. Semaphorin 3A elevates endothelial cell permeability through PP2A inactivation. J Cell Sci 2012; 125: 4137-46.
- Thirant C, Galan-Moya EM, Dubois LG, Pinte S, Chafey P, Broussard C, Varlet P, Devaux B, Soncin F, Gavard J, Junier MP, Chneiweiss H. Differential proteomic analysis of human glioblastoma and neural stem cells reveals HDGF as a novel angiogenic secreted factor. Stem Cells 2012; 30(5): 845-53.
- Dwyer J, Hebda JK, Le Guelte A, Galan-Moya EM, Smith SS, Azzi S, Bidere N, Gavard J. Glioblastoma Cell-Secreted Interleukin-8 Induces Brain Endothelial Cell Permeability via CXCR2. PLoS One 2012; 7(9): e45562.
2011
- Galan-Moya EM, Le Guelte A, Lima Fernandes E, Thirant C, Dwyer J, Bidere N, Couraud PO, Scott MG, Junier MP, Chneiweiss H, Gavard J. Secreted factors from brain endothelial cells maintain glioblastoma stem-like cell expansion through the mTOR pathway. EMBO Rep 2011; 12(5): 470-6.
- Galan Moya EM, Gavard J. Feeding the hungry enemy: an endothelial recipe for glioma stem cells. Cell Cycle 2011; 10(15): 2403-4.
- Carvalho G, Poalas K, Demian C, Hatchi E, Vazquez A, Bidere N. Participation of the cell polarity protein PALS1 to T-cell receptor-mediated NF-κB activation. PLoS One 2011; 6(3): e18159.
- Le Guelte A, Dwyer J, Gavard J. Jumping the barrier: VE-cadherin, VEGF and other angiogenic modifiers. Biol Cell 2011; 103(12): 593-605. Cover picture
- Le Guelte A, Gavard J. Permeability and barrier function in endothelial cell monolayer. In Permeability Barrier Methods and Protocols, Methods Mol Biol 2011; 763: 265-79.
- Dwyer J, Le Guelte A, Galan Moya EM, Sumbal M, Carlotti A, Douguet L, Gutkind JS, Grange PA, Dupin N, Gavard J. Remodeling of VE-cadherin junctions by the human herpes virus 8 G-protein coupled receptor. Oncogene 2011; 30(2): 190-200.
2010
- Carvalho G, Le Guelte A, Demian C, Vasquez A, Gavard J, Bidere N. Interplay between BCL10, MALT1 and IκBα during T-Cell receptor-mediated NF-κB activation. J Cell Sci 2010; 123: 2375-80.
- Beji Z, Hanini A, Smiri LS, Gavard J, Kacem K, Villain F, Greneche JM, Chau F, Ammar S. Magnetic properties of Zn-substituted MnFe2O4 nanoparticles synthesized in polyol as potential heating agents for hyperthermia. Evaluation of their toxicity on Endothelial cells. Chem Mater 2010; 22 (19): 5420-9.
- Sakurai A, Gavard J, Annas-Linhares Y, Basile JR, Amornphimoltham P, Palmby TR, Yagi H, Zhang F, Randazzo PA, Li X, Weigert R, Gutkind JS. Semaphorin 3E initiates anti-angiogenic signaling through Plexin-D1 by regulating Arf6 and R-Ras. Mol Cell Biol 2010; 30(12): 3086-98.
2009
- Gavard J, Hou X, Qu Y, Masedunskas A, Martin D, Weigert R, Li X, Gutkind JS.A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability. Mol Cell Biol 2009; 29(9): 2469-80.
- Gavard J. Breaking the VE-cadherin bonds. FEBS Lett 2009; 583(1): 1-6.
- Bidère N, Ngo VN, Lee J, Collins C, Zheng L, Wan F, Davis RE, Lenz G, Anderson DE, Arnoult D, Vazquez A, Sakai K, Zhang J, Meng Z, Veenstra TD, Staudt LM, Lenardo MJ. Casein kinase 1alpha governs antigen-receptor-induced NF-κB activation and human lymphoma cell survival. Nature 2009; 458(7234): 92-6.
