Research Highlight: The paracaspase MALT1 cleaves the LUBAC subunit HOIL1 during antigen receptor si

We report that the LUBAC subunit HOIL1 is cleaved by MALT1 following antigen receptor engagement. We further show that the overexpression of MALT1-insensitive HOIL1 mitigates T-cell receptor-mediated NF-kB activation and subsequent cytokine production in lymphocytes. Thus, our results unveil HOIL1 as a negative regulator of lymphocyte activation cleaved by MALT1.

by Tiphaine Douanne, Julie Gavard, Nicolas Bidère