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Journal Club: Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy

  • Mol Cell 2017 (65), Issue 5: 917–931
  • 6 mars 2017
  • 1 min de lecture

Highlights

- Glutamine deprivation and hypoxia result in ARD1-dependent PGK1 K388 acetylation - PGK1 functioning as a protein kinase phosphorylates Beclin1 at S30 - Beclin1 S30 phosphorylation enhances VPS34-Beclin1- ATG14L complex activity - Beclin1 S30 phosphorylation is required for autophagy initiation and tumorigenesis

 
 
 

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