Journal Club: Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy

Highlights

- Glutamine deprivation and hypoxia result in ARD1-dependent PGK1 K388 acetylation - PGK1 functioning as a protein kinase phosphorylates Beclin1 at S30 - Beclin1 S30 phosphorylation enhances VPS34-Beclin1- ATG14L complex activity - Beclin1 S30 phosphorylation is required for autophagy initiation and tumorigenesis