Research Highlight: Neutralizing gp130 interferes with endothelial-mediated effects on glioblastoma

The fundamental function of the factors emanating from endothelial cells in maintaining GSCs fate, plasticity, and survival urges to define the nature of these signals. We now report that anti-gp130 neutralizing antibodies halt patient-derived GSCs expansion cultured in the presence of the endothelial cell-conditioned media. Altogether, our work brings a different perspective on the function of gp130 signaling in GSCs, and will certainly foster new ideas and additional studies.