Journal Club: O2⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibil

• High-dose ascorbate sensitizes NSCLC and GBM cells to radio-chemotherapy

• O2⋅− and H2O2 increase labile iron causing cancer cell-selective ascorbate toxicity

• Therapeutic levels of ascorbate are achievable and well tolerated in GBM and NSCLC

• Cancer cell oxidative metabolism can be targeted with ascorbate for cancer therapy