Rechercher
Journal Club: O2⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibil
- Cancer Cell 2017; 31 (4): 487–500
- 10 mai 2017
- 1 min de lecture
• High-dose ascorbate sensitizes NSCLC and GBM cells to radio-chemotherapy
• O2⋅− and H2O2 increase labile iron causing cancer cell-selective ascorbate toxicity
• Therapeutic levels of ascorbate are achievable and well tolerated in GBM and NSCLC
• Cancer cell oxidative metabolism can be targeted with ascorbate for cancer therapy
Posts récents
Voir toutNature Cell Biology 2025 Abstract Cells secrete a large variety of extracellular vesicles (EVs) to engage in cell-to-cell and...