Journal Club: Molecular Checkpoint Decisions Made by Subverted Vascular Niche Transform Indolent Tum

A new study from Shahin Rafii' group @Cornell

Highlights

• Tumor endothelial cells (TECs) express checkpoint IGFBP7 suppressing tumor cells

• IGF1 induction in TECs expands chemoresistant cancer stem cell-expressing IGF1R

• FGFR1 activation in TECs induces ETS2 pathway to upregulate IGF1 and suppress IGFBP7

• FGF4 by priming FGFR1+ endothelial cells enables engraftment of chemoresistant CSCs