Rechercher
Journal Club: Molecular Checkpoint Decisions Made by Subverted Vascular Niche Transform Indolent Tum
- Cancer Cell 2017; 31(1): 110–26
- 19 juin 2017
- 1 min de lecture
A new study from Shahin Rafii' group @Cornell
Highlights
Tumor endothelial cells (TECs) express checkpoint IGFBP7 suppressing tumor cells
IGF1 induction in TECs expands chemoresistant cancer stem cell-expressing IGF1R
FGFR1 activation in TECs induces ETS2 pathway to upregulate IGF1 and suppress IGFBP7
FGF4 by priming FGFR1+ endothelial cells enables engraftment of chemoresistant CSCs
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