Journal Club: Llgl1 Connects Cell Polarity with Cell-Cell Adhesion in Embryonic Neural Stem Cells

#Vasioukhin #cellpolarity #cellcelladhesion #neuralstemcell #Dev_Cel

• LLGL1 loss in embryonic neural stem cells (ENSCs) results in cortical heterotopia

• LLGL1 is necessary for the maintenance of apical junctional complexes in ENSCs

• LLGL1 binds to and regulates cell-surface levels and localization of N-cadherin

• Disruption of the N-cadherin-LLGL1 interaction results in cortical heterotopia