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Journal Club: Llgl1 Connects Cell Polarity with Cell-Cell Adhesion in Embryonic Neural Stem Cells

  • Developmental Cell, 2007 : 41 (5): 481–495
  • 17 juil. 2017
  • 1 min de lecture
  • LLGL1 loss in embryonic neural stem cells (ENSCs) results in cortical heterotopia

  • LLGL1 is necessary for the maintenance of apical junctional complexes in ENSCs

  • LLGL1 binds to and regulates cell-surface levels and localization of N-cadherin

  • Disruption of the N-cadherin-LLGL1 interaction results in cortical heterotopia

 
 
 
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