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Journal Club: MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and

  • Immunity 2017, Volume 47, Issue 1, p51–65.e7
  • 4 sept. 2017
  • 1 min de lecture

Highlights

  • MLKL facilitates endosomal trafficking independently of induction of necroptosis

  • RIPK3 boosts release of phospho-MLKL-containing vesicles from cells

  • This release appears to withhold death and might contribute to cellular communication

  • The structural requirements for endosomal and necroptotic MLKL functions overlap

 
 
 

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