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Journal Club: MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and


Highlights

  • MLKL facilitates endosomal trafficking independently of induction of necroptosis

  • RIPK3 boosts release of phospho-MLKL-containing vesicles from cells

  • This release appears to withhold death and might contribute to cellular communication

  • The structural requirements for endosomal and necroptotic MLKL functions overlap

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