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Journal Club: Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Fun


  • BRD4 represses a program of autophagy and lysosome genes independently of MiT/TFE

  • BRD4 de-repression promotes certain types of autophagy, but not others

  • Nutrient deprivation de-represses BRD4 via AMPK signaling to promote cell survival

  • Oncoprotein BRD4-NUT is a potent repressor of autophagy and lysosome function

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