Journal Club: Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Fun

• BRD4 represses a program of autophagy and lysosome genes independently of MiT/TFE

• BRD4 de-repression promotes certain types of autophagy, but not others

• Nutrient deprivation de-represses BRD4 via AMPK signaling to promote cell survival

• Oncoprotein BRD4-NUT is a potent repressor of autophagy and lysosome function