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Rechercher

Journal Club: ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Gli

  • Cell Stem Cell 2017, 21(2): 209–24
  • 18 sept. 2017
  • 1 min de lecture

Highlights

  • GSCs can be classified into two subgroups based on ASCL1 expression

  • ASCL1 is required for GSCs to undergo neuronal lineage differentiation

  • ASCL1hi GSCs are responsive to Notch pathway inhibitors

  • ASCL1 binds closed chromatin to activate target genes that drive neuronal fate

 
 
 
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