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Journal Club: ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Gli
- Cell Stem Cell 2017, 21(2): 209–24
- 18 sept. 2017
- 1 min de lecture
Highlights
GSCs can be classified into two subgroups based on ASCL1 expression
ASCL1 is required for GSCs to undergo neuronal lineage differentiation
ASCL1hi GSCs are responsive to Notch pathway inhibitors
ASCL1 binds closed chromatin to activate target genes that drive neuronal fate
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