Journal Club: ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Gli

Highlights

• GSCs can be classified into two subgroups based on ASCL1 expression

• ASCL1 is required for GSCs to undergo neuronal lineage differentiation

• ASCL1hi GSCs are responsive to Notch pathway inhibitors

• ASCL1 binds closed chromatin to activate target genes that drive neuronal fate