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Research Highlight: Pharmacological targeting of apelin impairs glioblastoma growth
- Brain 2017
- 3 oct. 2017
- 1 min de lecture

Glioblastomas are aggressive brain tumours that contain a subpopulation of highly plastic self-renewing cancer cells. Harford-Wright et al. show that the vasoactive peptide apelin, secreted by brain endothelial cells, regulates glioblastoma patient-derived cells with stem-like properties. Pharmacological blockade of apelin hampers glioblastoma cell expansion and improves survival in xenografted mice.
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