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Journal Club: mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1

  • Molecular Cell 2017; 67(6): 922–35
  • 16 oct. 2017
  • 1 min de lecture

Highlights

  1. The mTORC1/4E-BPs/MTFP1/DRP1 axis controls mitochondrial dynamics

  2. Active-site mTOR inhibitors induce mitochondrial hyperfusion and branching

  3. mTORC1 regulates MTFP1 translation and mitochondrial recruitment of DRP1 via 4E-BPs

  4. Uncoupling MTFP1 levels from the mTORC1 axis upon mTOR inhibition leads to apoptosis

 
 
 

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