Journal Club: mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1

Highlights

1. The mTORC1/4E-BPs/MTFP1/DRP1 axis controls mitochondrial dynamics

2. Active-site mTOR inhibitors induce mitochondrial hyperfusion and branching

3. mTORC1 regulates MTFP1 translation and mitochondrial recruitment of DRP1 via 4E-BPs

4. Uncoupling MTFP1 levels from the mTORC1 axis upon mTOR inhibition leads to apoptosis