Rechercher
Journal Club: mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1
- Molecular Cell 2017; 67(6): 922–35
- 16 oct. 2017
- 1 min de lecture

Highlights
The mTORC1/4E-BPs/MTFP1/DRP1 axis controls mitochondrial dynamics
Active-site mTOR inhibitors induce mitochondrial hyperfusion and branching
mTORC1 regulates MTFP1 translation and mitochondrial recruitment of DRP1 via 4E-BPs
Uncoupling MTFP1 levels from the mTORC1 axis upon mTOR inhibition leads to apoptosis
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