Zika-Virus-Encoded NS2A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Prot

Highlights

• ZIKV-NS2A, but not DENV-NS2A, depletes RGCs in the embryonic mouse cortex

• ZIKV-NS2A expression causes mis-positioning of newborn neurons in the mouse cortex

• ZIKA-NS2A interacts with and depletes adherens junction (AJ) complex proteins

• ZIKV-NS2A impairs RGC proliferation and AJ formation in human forebrain organoids