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Zika-Virus-Encoded NS2A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Prot
- Cell Stem Cell 2017 21(3): 349–58.
- 13 nov. 2017
- 1 min de lecture
Highlights
ZIKV-NS2A, but not DENV-NS2A, depletes RGCs in the embryonic mouse cortex
ZIKV-NS2A expression causes mis-positioning of newborn neurons in the mouse cortex
ZIKA-NS2A interacts with and depletes adherens junction (AJ) complex proteins
ZIKV-NS2A impairs RGC proliferation and AJ formation in human forebrain organoids
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