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JournalClub: OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates MyD88-Dependent Signalin
- Molecular Cell 2018; 69(3): 505–16.
- 12 févr. 2018
- 1 min de lecture
Highlights
OTUD4 phosphorylation activates a K63-specific deubiquitinase activity
OTUD4 K63 deubiquitinase activity requires a ubiquitin-interacting motif
OTUD4 K63 deubiquitinase activity targets MyD88
Otud4−/− cells are hypersensitive to MyD88-dependent TLR signaling
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