JournalClub: OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates MyD88-Dependent Signalin

Highlights

OTUD4 phosphorylation activates a K63-specific deubiquitinase activity

OTUD4 K63 deubiquitinase activity requires a ubiquitin-interacting motif

OTUD4 K63 deubiquitinase activity targets MyD88

Otud4−/− cells are hypersensitive to MyD88-dependent TLR signaling