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Journal Club: Hypoxic Induction of Vasorin Regulates Notch1 Turnover to Maintain Glioma Stem-like Ce

  • Cell Stem Cell 2018, 22: 104–18
  • 18 févr. 2018
  • 1 min de lecture

Highlights

Vasorin maintains glioma stem-like cells GSCs) in the hypoxic niche


HIF1α/STAT3 co-activator complex induces Vasorin expression selectively in GSCs


Vasorin binds to and regulates membranous Notch1 turnover


Vasorin expression correlates with glioma aggressiveness

 
 
 

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