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JournalClub: Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Gliobla

  • Cancer Cell 017 Nov 13;32(5):590-607
  • 15 mai 2018
  • 1 min de lecture

  • TRF1 expression is increased in both human and mouse GBM

  • TRF1 inhibition impairs GBM initiation and progression in different mouse models

  • The mechanism involves telomeric DNA damage induction and reduced stemness

  • TRF1 chemical inhibitors inhibit xenograft growth from patient-derived primary GSCs

 
 
 

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