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JournalClub: Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Gliobla
- Cancer Cell 017 Nov 13;32(5):590-607
- 15 mai 2018
- 1 min de lecture
TRF1 expression is increased in both human and mouse GBM
TRF1 inhibition impairs GBM initiation and progression in different mouse models
The mechanism involves telomeric DNA damage induction and reduced stemness
TRF1 chemical inhibitors inhibit xenograft growth from patient-derived primary GSCs
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