Journal Club: PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Gra

Highlights

• Immune synapse formation triggers rapid changes in the membrane composition and charge

• PIP5K is a molecular sensor of TCR activation and is rapidly depleted at the synapse

• PIP5K distribution controls actin recruitment across the immune synapse

• Membrane specialization controls accessibility for centrosome docking and secretion