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Journal Club: Reciprocal Signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Pr


  • Differentiated tumor cells cooperate with glioma stem cells to promote tumor growth

  • Differentiated glioma cells secrete BDNF to stimulate NTRK2 on glioma stem cells

  • The neurotrophin BDNF induces glioma stem cells to secrete the VGF neuropeptide

  • VGF promotes survival and growth of both stem-like and differentiated tumor cells

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