Journal Club: Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injur
- Mol Cell 2018, in press
- 19 nov. 2018
- 1 min de lecture
Highlights
MLKL expression is induced in the Schwann cells of sciatic nerves following injury
MLKL is phosphorylated at serine 441 site in the Schwann cells of injured nerves
The serine 441 phospho-mimic MLKL breaks down myelin sheath in non-injured nerves
MLKL-mediated myelin breakdown promotes functional axon regeneration
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