Journal Club: Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome

Highlights

• Pacer is a regulator of hepatic autophagy and liver homeostasis

• Pacer is directly phosphorylated by mTORC1 under nutrient-rich conditions

• Dephosphorylated Pacer is acetylated by the GSK3-TIP60 pathway

• Pacer acetylation promotes autophagosome maturation and lipid metabolism