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Rechercher

Journal Club: Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome

  • Molecular Cell, Vol. 73, Issue 4, p788–802.e7
  • 25 févr. 2019
  • 1 min de lecture

Highlights

  • Pacer is a regulator of hepatic autophagy and liver homeostasis

  • Pacer is directly phosphorylated by mTORC1 under nutrient-rich conditions

  • Dephosphorylated Pacer is acetylated by the GSK3-TIP60 pathway

  • Pacer acetylation promotes autophagosome maturation and lipid metabolism

 
 
 
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