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Journal Club: Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome
- Molecular Cell, Vol. 73, Issue 4, p788–802.e7
- 25 févr. 2019
- 1 min de lecture
Highlights
Pacer is a regulator of hepatic autophagy and liver homeostasis
Pacer is directly phosphorylated by mTORC1 under nutrient-rich conditions
Dephosphorylated Pacer is acetylated by the GSK3-TIP60 pathway
Pacer acetylation promotes autophagosome maturation and lipid metabolism
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