Journal Club: O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Int

Highlights

• LPS treatment causes a decrease in HBP activity and protein O-GlcNAcylation

• OGT deficiency increases activation of innate immune response and necroptosis

• O-GlcNAcylation of RIPK3 on T467 inhibits RIPK3-RIPK1 and RIPK3-RIPK3 interaction