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Rechercher

Journal Club: O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Int

  • Immunity 2019
  • 4 mars 2019
  • 1 min de lecture

Highlights

  • LPS treatment causes a decrease in HBP activity and protein O-GlcNAcylation

  • OGT deficiency increases activation of innate immune response and necroptosis

  • O-GlcNAcylation of RIPK3 on T467 inhibits RIPK3-RIPK1 and RIPK3-RIPK3 interaction

 
 
 
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