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Journal Club: MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activi
- Volume 73, ISSUE 6, Molecular Cell
- 26 mars 2019
- 1 min de lecture
Highlights
TNFα induces the recruitment of MST1 to the TNFR1 signaling complex (TNF-RSC)
TRAF2 is required for the TNFα-induced activation of MST1 within the TNF-RSC
MST1 phosphorylates HOIP in TNF-RSC, thereby inhibiting an E3 ligase activity of LUBAC
MST1 attenuates the LUBAC-mediated activation of the NF-κB pathway
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