Journal Club: MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activi

Highlights

• TNFα induces the recruitment of MST1 to the TNFR1 signaling complex (TNF-RSC)

• TRAF2 is required for the TNFα-induced activation of MST1 within the TNF-RSC

• MST1 phosphorylates HOIP in TNF-RSC, thereby inhibiting an E3 ligase activity of LUBAC

• MST1 attenuates the LUBAC-mediated activation of the NF-κB pathway