Highlight: CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1

• A subset of CYLD is found at the centriolar satellites

• CYLD maintains the proteostasis of the centriolar satellites

• CYLD removes ubiquitin chains bound to the E3 ligase MIB1

• CYLD counteracts MIB1-mediated disruption of the centriolar satellites