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Journal Club: Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Beh

Highlights

  • Peripheral CD4 + T cells control stress-induced anxiety-like behavior

  • Mitochondrial fission in peripheral CD4 + T cell causes severe anxiety symptoms

  • T cell-derived xanthine acts on the oligodendrocytes in the left amygdala

  • IRF-1 controls purine synthesis in CD4 + T cells and triggers the onset of anxiety

 
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