Journal Club: Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Beh

Highlights

• Peripheral CD4 + T cells control stress-induced anxiety-like behavior

• Mitochondrial fission in peripheral CD4 + T cell causes severe anxiety symptoms

• T cell-derived xanthine acts on the oligodendrocytes in the left amygdala

• IRF-1 controls purine synthesis in CD4 + T cells and triggers the onset of anxiety