Journal Club: mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux

Highlights

• DRAM-1 is required for efficient activation of the nutrient-sensing complex mTORC1

• DRAM-1 and SCAMP3 direct newly synthesized amino acid transporters to lysosomes

• DRAM-1 drives lysosomal amino acid efflux to promote mTORC1 activation

• Loss of DRAM-1 increases insulin sensitivity and enhances adipocyte differentiation