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Journal Club: Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis


Highlights

  • ZIKV preferentially infects glioblastoma stem cells (GSCs) rather than neural precursor cells

  • ZIKV kills SOX2 + cells from a diverse array of malignant brain tumors

  • SOX2 determines susceptibility to ZIKV infection with reduced antiviral responses

  • Integrin α vβ 5 is a GSC marker and promotes Zika virus infection of GSCs

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