Journal Club: Differentiation Drives Widespread Rewiring of the Neural Stem Cell Chaperone Network

NPSC differentiation alters proteostasis strategies by rewiring chaperone network
High TRiC/CCT in NSPCs promotes proteome solubility and stress resilience
sHSP induced in neural progeny detoxify misfolded proteins by spatial sequestration
Widespread decline in TRiC/CCT levels and NSPC proteostasis in brain aging