Journal Club: Differentiation Drives Widespread Rewiring of the Neural Stem Cell Chaperone Network
- Molecular Cell 2020
- 27 avr. 2020
- 1 min de lecture
Highlights
NPSC differentiation alters proteostasis strategies by rewiring chaperone network
High TRiC/CCT in NSPCs promotes proteome solubility and stress resilience
sHSP induced in neural progeny detoxify misfolded proteins by spatial sequestration
Widespread decline in TRiC/CCT levels and NSPC proteostasis in brain aging
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