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Journal Club: LUBAC accelerates B-cell lymphomagenesis by conferring B cells resistance to genotoxic

  • Blood 2020
  • 2 juin 2020
  • 1 min de lecture

Key Points

  • LUBAC accelerates B-cell lymphomagenesis through protection of DNA damage-induced apoptosis, thereby promoting AID-mediated mutations.

  • Inhibition of LUBAC by small molecules is a promising therapeutic strategy for B-cell lymphomas with NF-kB activation.

 
 
 

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