Journal Club: Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Ne

Highlights

• Non-cleavable caspase-8 (caspase-8 DA) causes inflammation, blocked by necroptosis

• Inflammation in Casp8DA/DAMlkl−/− mice is prevented by ablation of one allele of Fadd

• Full deletion of Fadd in Casp8DA/DAMlkl−/− mice causes Casp1-dependent lethality

• Non-cleavable caspase-8 induces ASC oligomerization in absence of FADD