Journal Club: The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exoc

Highlights

• Tissue acidification is a major chemical hallmark of the tumor microenvironment

• PRL-expressing cells can grow in an acidic environment (acid addiction)

• PRL causes acid addiction of cells by stimulating lysosomal exocytosis

• TRPML is crucial for lysosomal exocytosis, acid addiction, and metastasis by PRL