Highlight

Necrosulfonamide causes oxidation of PCM1 and impairs ciliogenesis and autophagy

iScience 2024

Highlights

• Necrosulfonamide (NSA) functions as a redox cycler independently of MLKL
  

• PCM1 and several centriolar satellite components are redox sensor proteins
  

• NSA-mediated ROS production prevents the formation of primary cilia
  

• NSA interferes with autophagy partly via PCM1