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- nbidere
- 8 avr. 2024
- 1 min de lecture
Necrosulfonamide causes oxidation of PCM1 and impairs ciliogenesis and autophagy
iScience 2024
Highlights
Necrosulfonamide (NSA) functions as a redox cycler independently of MLKL
PCM1 and several centriolar satellite components are redox sensor proteins
NSA-mediated ROS production prevents the formation of primary cilia
NSA interferes with autophagy partly via PCM1
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