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  • nbidere
  • 16 sept. 2022
  • 1 min de lecture

Inhibition of the pseudokinase MLKL alters extracellular vesicle release and reduces tumor growth in glioblastoma

iScience 2022





Highlights

  • The pseudokinase MLKL governs extracellular vesicle release in glioblastoma cells

  • Blocking MLKL is deleterious to glioblastoma cell expansion in vitro and in vivo

  • MLKL action in glioblastoma patient cells does not involve necroptosis death

  • MLKL inhibition potentiates TMZ-induced cell death in glioblastoma patient cells


 
 
 

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