Highlight: Forum in Trends in Cancer

A lysosomal requiem for glioblastoma cells

Laura Merlet, Margaux Le Guyon, Julie Gavard

Abstract

Once viewed solely as degradative compartments, lysosomes shape cell fate through signaling, metabolism, and communication. In glioblastoma, their rewiring underlies plasticity, invasion, and resistance to therapies. This forum explores lysosomal dynamics in brain tumors and therapeutic strategies targeting lysosomal vulnerabilities, offering fresh perspectives for precision approaches in this lethal cancer.