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Highlight: The paracaspase MALT1 controls cholesterol homeostasis in glioblastoma stem-like cells through lysosome proteome shaping

Maghe et al, Cell Reports 2024







Highlights


  • Matched-omic approach shows that the paracaspase MALT1 adjusts cholesterol level

  • MALT1 blockage causes cholesterol sequestration in supernumerary lysosomes

  • MALT1 prevents cholesterol transporter exhaustion and lysosomal proteome editing

  • The targeting of NPC1 abrogates glioblastoma cell viability

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