Highlight: The paracaspase MALT1 controls cholesterol homeostasis in glioblastoma stem-like cells through lysosome proteome shaping

Maghe et al, Cell Reports 2024

Highlights

• Matched-omic approach shows that the paracaspase MALT1 adjusts cholesterol level

• MALT1 blockage causes cholesterol sequestration in supernumerary lysosomes

• MALT1 prevents cholesterol transporter exhaustion and lysosomal proteome editing

• The targeting of NPC1 abrogates glioblastoma cell viability