Rechercher
Journal Club:
- nbidere
- 25 janv. 2021
- 1 min de lecture
Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes
Cell, Volume 184, Issue 1, 7 January 2021, Pages 149-168.e17
Highlights • Of several cytokines tested, only synergism of TNF-α and IFN-γ induces PANoptosis
• TNF-α and IFN-γ-mediated PANoptosis perpetuates cytokine storm
• TNF-α and IFN-γ shock mirrors cytokine storm syndromes, including COVID-19
• Neutralizing TNF-α and IFN-γ protects against SARS-CoV-2, HLH, and sepsis in mice
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