Journal Club:

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

Cell, Volume 184, Issue 1, 7 January 2021, Pages 149-168.e17

Highlights • Of several cytokines tested, only synergism of TNF-α and IFN-γ induces PANoptosis

• TNF-α and IFN-γ-mediated PANoptosis perpetuates cytokine storm

• TNF-α and IFN-γ shock mirrors cytokine storm syndromes, including COVID-19

• Neutralizing TNF-α and IFN-γ protects against SARS-CoV-2, HLH, and sepsis in mice