Journal Club

A conserved family of immune effectors cleaves cellular ATP upon viral infection

Cell 2024

Highlights

• The CBASS immune effector Cap17 is an ATP nucleosidase
  

• Defensive ATP nucleosidases in bacteria degrade ATP and dATP to block phage
  

• ATP nucleosidases are part of Detocs, a bacterial two-component anti-phage defense system
  

• ATP nucleosidases, common in bacteria, are also found in eukaryotic innate immune factors