Journal Club

A Selective Autophagy Pathway for Phase-Separated Endocytic Protein Deposits

Molecular Cell Volume 80, Issue 5, 3 December 2020, Pages 764-778.e7

Highlights •Ede1 is an intrinsic autophagy receptor for aberrant CME protein assemblies

•Aberrant CME assemblies form by liquid-liquid phase separation

•Liquid-liquid phase separation of Ede1 is important for autophagic degradation

•Ultrastructural view of an LLPS compartment at the PM and within autophagic bodies