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Rechercher

Journal Club

  • nbidere
  • 11 juin 2024
  • 1 min de lecture

Identification of hypoxic macrophages in glioblastoma with therapeutic potential for vasculature normalization


Cancer Cell Volume 42, Issue 5, 13 May 2024, Pages 815-832.e12



Highlights


  • Single-cell omics reveals functional and spatial diversity of Mo-TAMs in glioblastomas


  • Tumor cues and hypoxia concertedly induce Hypoxia-TAM signature via activating p50


  • ADM secreted by Hypoxia-TAM stimulates a destabilized tumor vasculature


  • ADM blockade improves vessel integrity, drug delivery, and anti-tumor efficacy


 
 
 

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