Journal Club
- nbidere
- 11 juin 2024
- 1 min de lecture
Identification of hypoxic macrophages in glioblastoma with therapeutic potential for vasculature normalization
Cancer Cell Volume 42, Issue 5, 13 May 2024, Pages 815-832.e12
Highlights
Single-cell omics reveals functional and spatial diversity of Mo-TAMs in glioblastomas
Tumor cues and hypoxia concertedly induce Hypoxia-TAM signature via activating p50
ADM secreted by Hypoxia-TAM stimulates a destabilized tumor vasculature
ADM blockade improves vessel integrity, drug delivery, and anti-tumor efficacy
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