Journal Club

Identification of hypoxic macrophages in glioblastoma with therapeutic potential for vasculature normalization

Cancer Cell Volume 42, Issue 5, 13 May 2024, Pages 815-832.e12

Highlights

• Single-cell omics reveals functional and spatial diversity of Mo-TAMs in glioblastomas

• Tumor cues and hypoxia concertedly induce Hypoxia-TAM signature via activating p50

• ADM secreted by Hypoxia-TAM stimulates a destabilized tumor vasculature

• ADM blockade improves vessel integrity, drug delivery, and anti-tumor efficacy