Journal Club

RNA aggregates harness the danger response for potent cancer immunotherapy

Cell Article| Volume 187, ISSUE 10, P2521-2535.e21, May 09, 2024

Highlights

• RNA-LPAs mimic dangerous emboli for lymphoreticular entrapment and systemic immunity

• Systemic immunity resets both the peripheral and intratumoral milieu via IFNAR1/RIG-I

• RNA-LPAs are safe and effective tumor re-modulators in canines with spontaneous gliomas

• RNA-LPAs reprogram the TME and elicit adaptive immunity in human GBM patients