Journal Club

Macrophage-mediated myelin recycling fuels brain cancer malignancy

CELL Volume 187, Issue 19p5336-5356.e30September 19, 2024

Highlights

• TAMs recycle cholesterol-rich myelin, acquiring lipid-laden features in glioblastoma

• Epigenetic rewiring induced by myelin debris scavenging underlies LLM immunosuppressive features

• LLMs transfer myelin-derived lipids to glioblastoma cells to fuel disease progression

• LLMs correlate with aggressive mesenchymal subtype and poor prognosis in patients