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Journal Club
- nbidere
- 23 sept. 2024
- 1 min de lecture
Macrophage-mediated myelin recycling fuels brain cancer malignancy
CELL Volume 187, Issue 19p5336-5356.e30September 19, 2024
Highlights
• TAMs recycle cholesterol-rich myelin, acquiring lipid-laden features in glioblastoma
• Epigenetic rewiring induced by myelin debris scavenging underlies LLM immunosuppressive features
• LLMs transfer myelin-derived lipids to glioblastoma cells to fuel disease progression
• LLMs correlate with aggressive mesenchymal subtype and poor prognosis in patients
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