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Journal Club

Alterations of ceramide synthesis induce PD-L1 internalization and signaling to regulate tumor metastasis and immunotherapy response


Cell Reports Volume 43, Issue 8, 27 August 2024, 114532





Highlights


  • CerS4 knockdown drives migration/metastasis via Shh/TGF-β signaling and PD-L1 internalization


  • The PD-L1/caprin-1 complex selectively stabilizes key mRNAs to promote migration/metastasis


  • Targeting CerS4/PD-L1/caprin-1/Shh axis sensitized metastatic breast cancer to immunotherapy



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