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Single-cell atlas of endothelial and mural cells across primary and metastatic brain tumors
Highlights
• Single-cell and bulk RNA-seq of the vasculature in human gliomas and BrMs
• High-grade GBMs exhibit significant transcriptional and spatial vascular alterations
• Low-grade gliomas, by contrast, closely resemble non-tumor brain tissue
• GBM and BrMs differ in their interactions with specific immune cells
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