Journal Club

Single-cell atlas of endothelial and mural cells across primary and metastatic brain tumors

Highlights

• Single-cell and bulk RNA-seq of the vasculature in human gliomas and BrMs

• High-grade GBMs exhibit significant transcriptional and spatial vascular alterations

• Low-grade gliomas, by contrast, closely resemble non-tumor brain tissue

• GBM and BrMs differ in their interactions with specific immune cells