Journal Club
- nbidere
- 16 juin
- 1 min de lecture
Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs
Cell May 2025
LAG3 undergoes rapid non-degradative polyubiquitination upon ligand engagement
Ligand-induced ubiquitination activates LAG3 by releasing its tail from the membrane
LAG3 ubiquitination is required for its suppression of antitumor immunity in vivo
LAG3/CBL coexpression identifies patients likely to respond to LAG3 blockade therapy
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