Journal Club
- nbidere
- 23 juin
- 1 min de lecture
Red blood cells undergo lytic programmed cell death involving NLRP3
Cell, May 2025
Highlights
• Complement activation induces a programmed death of RBCs, termed spectosis
• Assembly of miniNLRP3-ASC complex elicits caspase-8 maturation in RBCs
• Activated caspase-8 initiates β-spectrin proteolysis, causing hemolysis
• Suppressing miniNLRP3-signal-mediated β-spectrin breakdown alleviates hemolysis
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