Journal Club
- nbidere
- 30 juin
- 1 min de lecture
Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS
Cell 2025
• Viral protein activities that perturb centromeres are detected by the DNA sensor cGAS
• HSV-1 ICP0 protein triggers centromeric DNA amplification by translesion synthesis
• HSV-1 suppresses translesion synthesis with UL36USP to evade cGAS activation
• VICAR reveals a role of centromeres in immune activation beyond mitosis
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