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Journal Club

  • nbidere
  • il y a 4 jours
  • 1 min de lecture

Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS


Cell 2025


Highlights
Highlights

• Viral protein activities that perturb centromeres are detected by the DNA sensor cGAS


• HSV-1 ICP0 protein triggers centromeric DNA amplification by translesion synthesis


• HSV-1 suppresses translesion synthesis with UL36USP to evade cGAS activation


• VICAR reveals a role of centromeres in immune activation beyond mitosis


 
 
 

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