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Journal Club
- nbidere
- 25 mai 2021
- 1 min de lecture
Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis
Cell 2021, online
Highlights • Human neutrophils release ELANE to selectively kill a wide range of cancer cells
• ELANE’s anti-cancer function is silenced in murine neutrophils by SLPI
• ELANE proteolysis liberates the CD95 death domain to selectively kill cancer cells
• ELANE attenuates tumor growth and induces a CD8+ T cell-mediated abscopal effect
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