Journal Club

Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis

Cell 2021, online

Highlights • Human neutrophils release ELANE to selectively kill a wide range of cancer cells

• ELANE’s anti-cancer function is silenced in murine neutrophils by SLPI

• ELANE proteolysis liberates the CD95 death domain to selectively kill cancer cells

• ELANE attenuates tumor growth and induces a CD8+ T cell-mediated abscopal effect