Journal Club

Mitocytosis, a migrasome-mediated mitochondrial quality-control process

Cell, VOLUME 184, ISSUE 11, P2896-2910.E13

Highlights

• Mild mitochondrial stress triggers disposal of damaged mitochondria by migrasomes

• In this process (mitocytosis), motor proteins selectively bind damaged mitochondria

• Damaged mitochondria become localized at the cell periphery to facilitate mitocytosis

• Mitocytosis maintains mitochondrial quality and viability in neutrophils in vivo