Journal Club

Cilium induction triggers differentiation of glioma stem cells

Volume 36, ISSUE 10, 109656, September 07, 2021

Highlights

• Cilium checkpoint regulates self-renewal and differentiation of neural stem cells

• GSCs have suppressed ciliogenesis and thus have no cilium checkpoint

• Reintroducing of cilia in GSCs switches them from self-renewal to differentiation state

• GSCs reintroduced with cilia do not invade brain organoids