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Journal Club
- nbidere
- 11 oct. 2021
- 1 min de lecture
OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin
Mol Cell 2021; 81(15):3187-3204
Highlights • Otulin deletion in mice leads to arteriovenous malformations and embryonic lethality
• Linear ubiquitination of ALK1 decreases downstream Smad1/5 signaling
• The survival of Otulin-deficient mice is prolonged by BMP9 and ALK1Q200D knockin
• HOIP inhibitor restricts angiogenesis of ECs from ALK1-related HHT2 patients
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