Journal Club

OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin

Mol Cell 2021; 81(15):3187-3204

Highlights • Otulin deletion in mice leads to arteriovenous malformations and embryonic lethality

• Linear ubiquitination of ALK1 decreases downstream Smad1/5 signaling

• The survival of Otulin-deficient mice is prolonged by BMP9 and ALK1Q200D knockin

• HOIP inhibitor restricts angiogenesis of ECs from ALK1-related HHT2 patients